Irreversible myxoedema after lithium carbonate.

Fatal self-poisoning with lithium carbonate.

In a fatal case of self-poisoning with lithium carbonate there was a progressive increase in serum lithium concentration for 48 hours after ingestion of the overdose. It is suggested that the continuous increase in serum lithium concentration reflects prolonged absorption of lithium from relatively insoluble aggregates of lithium carbonate in the gastrointestinal tract. In this case there was a...

Lithium carbonate--a competitive aldosterone antagonist?

Plasma renin activity (PRA), aldosterone (aldo) levels, electrolyte levels, and blood pressures were measured in 16 patients with affective disorders taking lithium prophylactically, and in 16 age and sex-matched control subjects. PRA and aldo levels were significantly elevated in the lithium-treated group. There was no difference between the groups in plasma electrolytes or erect and supine bl...

Intestinal vasculitis and lithium carbonate-associated diarrhoea.

Lithium carbonate is now frequently used in the treatment of both unipolar and bipolar manic depressive states. It is generally thought that the adverse reactions of this drug are associated with plasma levels above the therapeutic range of 0.8-1.2 mmol/ litre, but they may also be associated with long-term usage of the medication within the recommended plasma concentrations. (Persson, 1977). T...

Mechanism of Lithium Carbonate Induced Hyperdipsia

used for the treatment of some psychiatric disorders (Marples, Christensen , Christensen , Ottosen and Nielsen, 1995). Many bipolar disorder patients become stabilized during the administration of lithium carbonate. Nevertheless, it produces several unwanted side effects, including polydipsia and polyuria (Penney and Hampton, 1990). At present, it is not clear the origin and mechanism of these ...

TERATOGENIC EFFECTS OF LITHIUM CARBONATE ON DEVELOPMENT OF MOUSE EMBRYOS